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17

抑制剂 & 化合物

3

天然产物

15

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T69666 MMP-8 Inhibitor I

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.
T81777 MMP-9-IN-8

MMP-9-IN-8(Compound 3)是MMP-9抑制剂,10 μM浓度下抑制活性为42.16%,50 μM时达58.28%。该化合物展现抗癌活性,能诱导MCF-7细胞凋亡,IC50为23.42 μM。
T61271 MMP2-IN-3

MMP Proteases/Proteasome
MMP2-IN-3是一种有效的基质金属蛋白酶(MMP-2)抑制剂( IC50 值:31 μM)。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ,其 IC50 分别为 26.6 和 32 μM。
T15055 DB04760

MMP-13 Inhibitor

MMP Proteases/Proteasome
DB04760 是一种高选择性和有效的 MMP-13 非锌螯合抑制剂(IC50:8 nM)。DB04760 能明显降低紫杉醇的神经毒性,并具有抗癌活性。
T38378 Dnp-PLAYWAR (trifluoroacetate salt)

Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26. The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T13358 XL-784

MMP Proteases/Proteasome
XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T36361 Dnp-PLALWAR (trifluoroacetate salt)

Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8. The activity of MMP-1 and MMP-8 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T24775 SD-2590 HCl

SD2590 HCl,SD-2590 Hydrochloride,SD2590 Hydrochloride,SD 2590 Hydrochloride

SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.
T13357 XL-784 free base

Others Others
XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T76017 CTTHWGFTLC, CYCLIC TFA

CTTHWGFTLC, CYCLIC TFA 是一种基质金属蛋白酶 MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为 8 μM。
T60551 MMP2-IN-2

MMP2-IN-2 (化合物 42) 是一种有效且选择性的MMP-2(基质金属蛋白酶)抑制剂,其IC50值为 4.2 μM。它 对MMP-13、MMP-9和MMP-8也具有抑制活性,IC50值分别为 12、23.3 和 25 μM。
T37983 GM 1489

GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor...
T78436 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

MMP Proteases/Proteasome
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) 是一种用于实时定量测定基质金属蛋白酶(MMP)酶活性的猝灭荧光肽底物。该化合物是MMP底物(FS-1)的衍生物,对胶原酶MMP-1、MMP-8MMP-13及MT1-MMP的特异性常数更高,具备较强的底物特异性。荧光激发与发射波长分别为325 nm和400 nm。
T68012 rebimastat

Rebimastat 是基于巯基的第二代基质金属蛋白酶(MMP)抑制剂,具有潜在的抗肿瘤活性。利莫司他选择性抑制几种 MMPs (MMP 1、2、8、9和14),从而诱导细胞外基质降解,抑制血管生成、肿瘤生长、侵袭和转移。
T41079 MMP13-IN-2

MMP13-IN-2

MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
T80242 TNO211

MMP Proteases/Proteasome
TNO211为具备生物活性的肽,主要研究对象是基质金属蛋白酶(MMP),一类能够降解多种细胞外基质蛋白并调控诸多生物活性分子的肽链内切酶家族。MMP在细胞表面受体裂解、凋亡配体释放及趋化因子/细胞因子失活等过程中起作用,同时与细胞增殖、迁移(粘附/分散)、分化、血管生成、细胞凋亡及宿主防御等生物行为密切相关。TNO211可靶向MMP-2、8、12、13和14,包含MMP特定可裂解的Gly-Leu键,并具有EDANS/DABCYL荧光标记,其荧光检测在监测内皮细胞培养基和患者滑液中的MMP活性方面表现出高灵敏度。吸光度/电磁场测量参数为340/490 nm。
T28251 ONO-8809

ONO8809

ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area i

化合物

MMP-8 Inhibitor I
Cat.No: T69666
Synonym:
Target:
MMP-9-IN-8
Cat.No: T81777
Synonym:
Target:
MMP2-IN-3
Cat.No: T61271
Synonym:
Target: MMP
DB04760
Cat.No: T15055
Synonym: MMP-13 Inhibitor
Target: MMP
Dnp-PLAYWAR (trifluoroacetate salt)
Cat.No: T38378
Synonym:
Target:
XL-784
Cat.No: T13358
Synonym:
Target: MMP
Dnp-PLALWAR (trifluoroacetate salt)
Cat.No: T36361
Synonym:
Target:
SD-2590 HCl
Cat.No: T24775
Synonym: SD2590 HCl,SD-2590 Hydrochloride,SD2590 Hydrochloride,SD 2590 Hydrochloride
Target:
XL-784 free base
Cat.No: T13357
Synonym:
Target: Others
CTTHWGFTLC, CYCLIC TFA
Cat.No: T76017
Synonym:
Target:
MMP2-IN-2
Cat.No: T60551
Synonym:
Target:
GM 1489
Cat.No: T37983
Synonym:
Target:
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
Cat.No: T78436
Synonym:
Target: MMP
rebimastat
Cat.No: T68012
Synonym:
Target:
MMP13-IN-2
Cat.No: T41079
Synonym: MMP13-IN-2
Target:
TNO211
Cat.No: T80242
Synonym:
Target: MMP
ONO-8809
Cat.No: T28251
Synonym: ONO8809
Target:
Cat. No. Product Name Target Signaling Pathways
T5S1026 Apigenin-7-glucuronide

Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

MMP Proteases/Proteasome
Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性,其对 MMP-3 (IC50:12.87 μM),MMP-8 (IC50:22.39 μM),MMP-9 (IC50:17.52 μM),MMP-13 (IC50:0.27 μM)。
T3850 Luteolin 7-O-glucuronide

Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷

MMP Proteases/Proteasome
Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) 是一种自由基清除剂,能够抑制基质金属蛋白酶的活性,其对 MMP-1,MMP-3,MMP-8MMP-9,MMP-13的IC50值分别为 17.63,7.99,11.42,12.85,0.03 μM。
T14121 Actinonin

(-)-Actinonin

Aminopeptidase Metabolism
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

天然产物

Apigenin-7-glucuronide
Cat.No: T5S1026
Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸
Target: MMP
Luteolin 7-O-glucuronide
Cat.No: T3850
Synonym: Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷
Target: MMP
Actinonin
Cat.No: T14121
Synonym: (-)-Actinonin
Target: Aminopeptidase
Cat. No. Product Name Species Expression System
TMPY-01884 MMP-8 Protein, Human, Recombinant

CLG1,HNC,PMNL-CL,matrix metallopeptidase 8,MMP<...

Human HEK293 Cells
MMP-8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 52 kDa and the accession number is P22894.
TMPY-01377 MMP-8 Protein, Human, Recombinant (His)

MMP-8,HNC,matrix metallopeptidase 8

Human HEK293 Cells
MMP-8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.6 kDa and the accession number is P22894.
TMPK-01286 MMP-8 Protein, Cynomolgus, Recombinant (His)

Collagenase 2,HNC,CLG1,MMP8,PMNL-CL

Cynomolgus HEK293 Cells
Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was signifi...
TMPY-01844 MMP-8 Protein, Mouse, Recombinant

BB138268,matrix metallopeptidase 8

Mouse HEK293 Cells
MMP-8 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 52 kDa and the accession number is O70138.
TMPY-00520 MMP-8 Protein, Mouse, Recombinant (His)

BB138268,matrix metallopeptidase 8

Mouse CHO Cells
MMP-8 Protein, Mouse, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 52.2 kDa and the accession number is O70138.
TMPY-05717 Integrin alpha V beta 8 Protein, Human, Recombinant (His)

Integrin alpha V β8,Integrin α V β 8

Human HEK293 Cells
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This m...
TMPY-04123 CEACAM1 Protein, Human, Recombinant (His & hFc)

CEACAM‑1,carcinoembryonic antigen-related cell adhesion mole...

Human HEK293 Cells
CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
TMPJ-01060 CXCL6 Protein, Human, Recombinant (His)

SCYB6,Chemokine Alpha 3,CKA-3,GCP2,GCP-2,C-X-C Motif Chemoki...

Human HEK293 Cells
Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. It is a potent neutrophil chemotactic and activating factor and it exhibits extensive similarity to other CXC chemokines such as IL-8 and ENA-78. CXCL6 can promote the release of MMP-9 from granulocytes indicating its potential role as an inflammatory mediator. It functionally uses both of the IL-8/CXCL8 receptors to chemoattract neutrophils but that is structurally most related to epithelial cell...
TMPH-01705 Mucin-1/MUC1 Protein, Human, Recombinant (His)

Human E. coli
Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPJ-00808 CD45RA Protein, Human, Recombinant (His)

PTPRC,CD45R,CD45,LCA,protein tyrosine phosphatase, receptor ...

Human HEK293 Cells
CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPJ-00828 Tau-F Protein, Human, Recombinant

Neurofibrillary tangle protein,Paired helical filament-tau,M...

Human E. coli
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPY-00717 CEACAM1 Protein, Human, Recombinant (His)

CEACAM‑1,BGP1,BGP,carcinoembryonic antigen-related cell adhe...

Human HEK293 Cells
CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8.
TMPY-06707 Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)

ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surface associa...

Human HEK293 Cells
Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPJ-01330 CD299 Protein, Human, Recombinant (His & Flag)

DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami...

Human HEK293 Cells
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso...
TMPY-00668 APP/Protease nexin-II Protein, Human, Recombinant (hFc)

CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,APPI,...

Human HEK293 Cells
APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.

重组蛋白

MMP-8 Protein, Human, Recombinant
Cat.No: TMPY-01884
Species: Human
Expression System: HEK293 Cells
MMP-8 Protein, Human, Recombinant (His)
Cat.No: TMPY-01377
Species: Human
Expression System: HEK293 Cells
MMP-8 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01286
Species: Cynomolgus
Expression System: HEK293 Cells
MMP-8 Protein, Mouse, Recombinant
Cat.No: TMPY-01844
Species: Mouse
Expression System: HEK293 Cells
MMP-8 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00520
Species: Mouse
Expression System: CHO Cells
Integrin alpha V beta 8 Protein, Human, Recombinant (His)
Cat.No: TMPY-05717
Species: Human
Expression System: HEK293 Cells
CEACAM1 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-04123
Species: Human
Expression System: HEK293 Cells
CXCL6 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01060
Species: Human
Expression System: HEK293 Cells
Mucin-1/MUC1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01705
Species: Human
Expression System: E. coli
CD45RA Protein, Human, Recombinant (His)
Cat.No: TMPJ-00808
Species: Human
Expression System: HEK293 Cells
Tau-F Protein, Human, Recombinant
Cat.No: TMPJ-00828
Species: Human
Expression System: E. coli
CEACAM1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00717
Species: Human
Expression System: HEK293 Cells
Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)
Cat.No: TMPY-06707
Species: Human
Expression System: HEK293 Cells
CD299 Protein, Human, Recombinant (His & Flag)
Cat.No: TMPJ-01330
Species: Human
Expression System: HEK293 Cells
APP/Protease nexin-II Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00668
Species: Human
Expression System: HEK293 Cells
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